Target Organ Toxicology Series - Developmental Toxicology

Deborah K. Hansen

• 22 oktober 2008
• 9781040173046

Samenvatting:

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs.

The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed.

Key topics include:

• the roles of apoptosis and signal transduction pathways in normal and abnormal development

• the role of epigenetic changes in development

• the role of nutrition and individual susceptibility

• the utility of bioinformatics

• global and targeted gene expression changes.