Testosterone

• 23 november 2011
• 9783642721878

Samenvatting:

The general chapter on pharmacol­ ogy and clinical uses of testosterone, in particular in male hypo­ gonadism, is extended by pharmacokinetic studies on testoster­ one preparations and individual substitution modalities using testosterone esters as well as implants and advanced trans dermal applications.

New developments in testosterone action and therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in 20 chapters. This 2nd edition has been thoroughly revised and extended. The book presents the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Effects on bones, muscles, lipids, hair, the prostate, and the brain are considered in separate chapters. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. The pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations are discussed in detail, and side effects of testosterone treatment are reviewed. This is the state-of-the-art book about testosterone action and therapy for endocrinologists, andrologists, urologists and pharmacologists.