Developments in Nephrology19-20- Nephrotoxicity in the exper ...

Edward A. Lock

• 13 oktober 2011
• 9789401080125

Samenvatting:

1. Fixation of renal tissue for cytochemical evaluation.- 2. The application of histochemistry at the light microscopic level to the study of nephrotoxicity.- 3. Cryomicrotomy of renal tissue, and the use of X-ray microanalysis and autoradiography at the light and electron microscopic levels.- 4. Fixation of kidney tissue for morphometric study.- 5. Correlating structural and functional changes in nephrotoxic renal injury.- 6. Naturally occurring renal disease in non-human primates.- 7. Chemically induced epithelial tumours and carcinogenesis of the renal parenchyma.- 8. Assessment of the kidney in relation to blood pressure regulation.- 9. Renal slices and perfusion.- 10. The use of single nephron techniques in renal toxicity studies.- 11. Prostaglandins and other eicosanoids.- 12. Xenobiotic metabolism in the mammalian kidney.- 13. Metabolism of glutathione in the kidney.- 14. Metabolic activation of halogenated chemicals and its relevance to nephrotoxicity.